0001001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 1001002 - Statement - Condensed Consolidated Balance Sheets (Unaudited) link:presentationLink link:calculationLink link:definitionLink 1002003 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1003004 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) link:presentationLink link:calculationLink link:definitionLink 1004005 - Statement - Condensed Consolidated Statement of Stockholders’ Equity (Unaudited) link:presentationLink link:calculationLink link:definitionLink 1005006 - Statement - Condensed Consolidated Statements of Cash Flow (Unaudited) link:presentationLink link:calculationLink link:definitionLink 2101101 - Disclosure - Nature of business and future operations link:presentationLink link:calculationLink link:definitionLink 2402401 - Disclosure - Nature of business and future operations (Details) link:presentationLink link:calculationLink link:definitionLink 2103102 - Disclosure - Significant accounting policies link:presentationLink link:calculationLink link:definitionLink 2204201 - Disclosure - Significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2405402 - Disclosure - Significant accounting policies (Details) link:presentationLink link:calculationLink link:definitionLink 2106103 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 2307301 - Disclosure - Fair value measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 2408403 - Disclosure - Fair value measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2409404 - Disclosure - Fair value measurements - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 2410405 - Disclosure - Fair value measurements - Changes in Fair Value of Liabilities-Classified as Stock Option (Details) link:presentationLink link:calculationLink link:definitionLink 2411406 - Disclosure - Fair value measurements - Changes in Fair Value of Contingent Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 2212202 - Disclosure - Fair Value Measures and Disclosures (Policies) link:presentationLink link:calculationLink link:definitionLink 2113104 - Disclosure - Investments in marketable securities link:presentationLink link:calculationLink link:definitionLink 2314302 - Disclosure - Investments in marketable securities (Tables) link:presentationLink link:calculationLink link:definitionLink 2415407 - Disclosure - Investments in marketable securities - Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 2416408 - Disclosure - Investments in marketable securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2117105 - Disclosure - Investment in Genevant link:presentationLink link:calculationLink link:definitionLink 2418409 - Disclosure - Investment in Genevant (Details) link:presentationLink link:calculationLink link:definitionLink 2119106 - Disclosure - Accounts payable and accrued liabilities link:presentationLink link:calculationLink link:definitionLink 2320303 - Disclosure - Accounts payable and accrued liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 2421410 - Disclosure - Accounts payable and accrued liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2122107 - Disclosure - Sale of future royalties link:presentationLink link:calculationLink link:definitionLink 2323304 - Disclosure - Sale of future royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 2424411 - Disclosure - Sale of future royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2425412 - Disclosure - Sale of future royalties - Liability Activity (Details) link:presentationLink link:calculationLink link:definitionLink 2126108 - Disclosure - Contingencies and commitments link:presentationLink link:calculationLink link:definitionLink 2427413 - Disclosure - Contingencies and commitments (Details) link:presentationLink link:calculationLink link:definitionLink 2128109 - Disclosure - Collaborations, contracts and licensing agreements link:presentationLink link:calculationLink link:definitionLink 2329305 - Disclosure - Collaborations, contracts and licensing agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 2430414 - Disclosure - Collaborations, contracts and licensing agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2131110 - Disclosure - Shareholders’ equity link:presentationLink link:calculationLink link:definitionLink 2332306 - Disclosure - Shareholders’ equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2433415 - Disclosure - Shareholders’ equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2434416 - Disclosure - Shareholders’ equity - Stock-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 2135111 - Disclosure - Related party transactions link:presentationLink link:calculationLink link:definitionLink 2436417 - Disclosure - Related party transactions (Details) link:presentationLink link:calculationLink link:definitionLink